Gemelli IRCCS, Rome, Italy Università Cattolica del Sacro Cuore, Rome, Italy. 2 Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia Dipartimento di Scienze dell'emergenza, anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A.1 Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Australia.